Facile Synthesis of Thiazolidin-4-one Derivatives Incorporating Indole Moiety

dc.contributor.author	A. Altamamy, Hussein.
dc.date.accessioned	2017-11-27T07:51:25Z
dc.date.accessioned	2024-10-24T17:52:04Z
dc.date.available	2017-11-27T07:51:25Z
dc.date.available	2024-10-24T17:52:04Z
dc.date.issued	2013
dc.description.abstract	Condensation of ethyl 3-formyl-1H-indole-2-carboxylate (1) with thiosemicarbazide in ethanol gave ethyl 3-(thiosemicarbazidomethyl)-1H-indole-2-carboxylate (2). Treatment of 2 with chloroacetic acid afforded the thiazolidin-4-one derivative 3. Condensation of 3 with aromatic aldehydes gave the corresponding arylidene derivatives 4a-c. Cyclization of 4a-c with hydroxylamine hydrochloride in the presence of sodium acetate yielded thiazolidino[4,5-c]isoxazoline derivatives 5a-c. The structure of the synthesized compounds were confirmed using elemental and spectroscopic analysis.	ar
dc.identifier.uri	https://repository.dll.edu.ly/handle/1/483
dc.language.iso	en	ar
dc.publisher	Sebha University	ar
dc.title	Facile Synthesis of Thiazolidin-4-one Derivatives Incorporating Indole Moiety	ar
dc.type	Article	ar

Files

Now showing 1 - 1 of 1